Supercritical antisolvent precipitation of cephalosporins. Applications of supercritical carbon dioxide as an antisolvent. Supercritical antisolvent precipitation of nanoparticles of a zinc oxide precursor. The liquid solution and the supercritical antisolvent are continuously. Membrane separation in supercritical antisolvent process for nanoparticle production kayoko ono master of science, december 2006 b. In this sense, several supercritical fluidbased techniques, employing mainly. Supercritical antisolvent micronization sas has been used to obtain microparticles of several kind of materials, but the production of nanoparticles have been observed and studied in some cases only. An overview of pharmaceutical applications bhupinder singh sekhon. Supercritical antisolvent processing, sas, particle production, modelling, feasibility, capital and manufacturing cost. Micronization of poly3hydroxybutyrate phb by the supercritical fluid antisolvent precipitation sas technique using supercritical carbon dioxide as an antisolvent was studied experimentally. Study of particle formation using supercritical co2 as an. In this work, a swirl mixer was employed to produce the micronized curcumin with polyvinylpyrrolidone pvp by the supercritical antisolvent. Micronization of curcumin with biodegradable polymer by. Also the sas process is quite flexible in terms of solvent choice.
Pdf particle formation and micronization using nonconventional. Meireles lasefidea department of food engineering, fea school of food engineering, unicamp university of. Overview of the use of scf to process biopolymers for. Micronization is a term used to describe size reduction where the resulting particle size is. Supercritical fluidsassisted micronization techniques. At this point it is not clear to what extent the nonexplosive regime will expand. Read supercritical antisolvent micronization of some biopolymers, the journal of supercritical fluids on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. B io p rocess technical engineering powder properties by. Micronization of pharmaceutical compounds using the supercritical antisolvent process yanping chen, yenming chen, department of chemical engineering, national taiwan university, no.
Nanoparticles production by supercritical antisolvent. The effect of system temperature and pressure on the fluiddynamic behavior of the supercritical antisolvent micronization proc ess 75. The fine particles are prepared by sudden reduction of the solubility 2 of the solvent when solution containing the issued materials and appropriate solvent is dissolved in supercritical solvent. Formation of polymer particles with supercritical fluids. Thus, the synthesis of ultrafine particles using sas has been reported in a number of studies e. Pdf micronized powders are of interest in many industrial fields. This work aims to study supercritical antisolvent micronization of marigold derived purified lutein that was dissolved in the mixture of hexane and ethyl acetate 70. First, some liquid expansion curves were experimentally produced to study the general behavior of the ternary systems antisolventsolventbiopolymer. Supercritical fluidsassisted micronization techniques 1297. Questo conteggio citato da include citazioni ai seguenti articoli in scholar. Supercritical antisolvent precipitation sas is based on the fast dissolution of a liquid solution in a supercritical fluid. Supercritical antisolvent micronization of some biopolymers. This work is focused on the systematic production of nanoparticles using sas.
Various supercritical particle formation technologies are briefly described, including processes in which the supercritical fluid acts as a solute, solvent, and antisolvent. Supercritical antisolvent micronization of pva by semi. Micronization of pharmaceutical compounds using the. Recent the journal of supercritical fluids articles recently published articles from the journal of supercritical fluids. The main factors for choosing the solvent and biodegradable. Supercritical carbon dioxide scco 2 is the supercritical fluid that is most widely used in precipitation and encapsulation processes due to its favorable characteristics, such as its low toxicity, low cost, easy removal and nonflammability, and among the existing supercritical encapsulation techniques, those using scco 2 as an antisolvent. Preparation of zein nanoparticles by using solutionenhanced dispersion with supercritical co2 and elucidation with computational fluid dynamics sining li, yaping zhao school of chemistry and chemical engineering, shanghai jiao tong university, shanghai, china abstract. Among them, supercritical carbon dioxide scco2 emerged as an excellent candidate. Supercritical antisolvent precipitation of phbv microparticles. Preparation of zein nanoparticles by using solution. Encapsulation of food compounds using supercritical. Supercritical antisolvent micronizacin of some biopolymers. Engineering and manufacturing science and technology, general atmospheric carbon dioxide biopolymers atomic properties usage chemical processes research particles chemical properties composition production processes.
The supercritical antisolvent sas process is used when a solute produced into fine particles is not soluble in the supercritical fluid. Trends in particle formation of bioactive compounds using. Abstract this thesis discusses particle production by supercritical antisolvent processing sas techniques by looking the fundamentals. In some cases, this allows a controlled production of different crystalline polymorphs or of amorphous particles, a very interesting feature for commercial. Supercritical antisolvent sas high pressure processes.
It was shown that sfs are suitable for the micronization of pharmaceuticals to obtain controlled drugdelivery systems. Integrated supercritical extraction and supercritical adsorption processes from passion fruit byproduct. Effect of supercritical fluid density on nanoencapsulated. Request pdf formation of polymer particles with supercritical fluids. Pharmaceutics 2019, 11, 21 2 of 18 the selection of processing technique with supercritical co 2 for biopolymers depend greatly on the interaction of the supercritical co2 with the active ingredient, coating material of interest, and suitable solvent. Supercritical antisolvent precipitation of nanoparticles of.
The optimum conditions were determined to be as follows. Supercritical antisolvent micronization of some biopolymers, j. Recently, supercritical fluids sfs have been used in applications closely related to biotechnology. Polymer coatingencapsulation of nanoparticles using a. The process of reducing average diameter of solid api to produce particles in the range of micrometer is called micronization. Letourneur, supercritical antisolvent micronization of some biopolymers, j. Role of excess molar enthalpies in supercritical antisolvent micronizations using dimethylsulfoxide as the polar solvent. Using the sas process, crystals, spherical nanoparticles, and microparticles with mean diameters ranging from 0. Particle design using supercritical co 2 has been of great interest in the pharmaceutical, microelectronic, catalytic, and related industries over the past 10 years. The possibility of preparing particles of varying morphology including hollow spheres and specified size from 100 nm to 20. Among the biopolymers, polyvinyl alcohol pva is widely recommended for pharmaceutical applications as carrier of active compounds, such as in the case of production of capsules or spheres for medical purposes. Sorry, we are unable to provide the full text but you may find it at the following locations. Supercritical antisolvent process for substituted paralinked aromatic polyamides.
Some nonbiodegradable but biocompatible polymers can also be used in drug. Supercritical antisolvent sas precipitation technique iii particles from gas saturated solutions pgss. Particle formation with supercritical fluids, volume 6. This technique has been tested to produce nanoparticles of yttrium, samarium, and neodymium acetates to be used as precursors of hightemperature superconductors. Particles formation using supercritical fluids 463 fig. This research involves experimental studies of supercritical fluid scfbased micronization and encapsulation processes exploiting both solvent and antisolvent properties of supercritical co 2 for diverse functional pigments to extend the application of these natural functional pigments. Supercritical antisolvent sas the supercritical anti solvent technique is a very flexible technique for the micronization of pharmaceutical and natural compounds. Some techniques have already become commercial namely extraction, e. The technique is based in putting into contact an organic solution with supercritical carbon dioxide. First, the reliability of homemade experimental apparatuses designed and constructed by our research group. Gas antisolvent gassupercritical antisolvent sas and related processes.
Application of supercritical antisolvent method in drug. First, some liquid expansion curves were experimentally produced to study the general behavior of the ternary systems antisolvent solventbiopolymer. Supercritical antisolvent sas high pressure processes group. Total panax notoginsenosides nanoparticles, typical multicomponent extracts from traditional chinese medicine, were prepared with a supercritical antisolvent sas process using ethanol as solvent and carbon dioxide as antisolvent. Supercritical antisolvent and some variants such as seds, gas and pca baldyga et. The journal of supercritical fluids vol 18, issue 3. The reported work demonstrates and discusses the effect of supercritical fluid density pressure and temperature of supercritical fluid carbon dioxide on particle size and distribution using the supercritical antisolvent sas method in the purpose of drug encapsulation. We processed various biopolymers by semicontinuous supercritical antisolvent precipitation sas to evaluate the possibility of producing nano and microparticles of controlled size and distribution. Extraction and precipitation particle coating using supercritical.
Pdf supercritical fluidsassisted micronization techniques. Supercritical antisolvent micronization of some biopolymers, journal. Supercritical fluids micronization techniques university of salerno department of chemical engineering. Gupta in supercritical antisolvent process to produce pharmaceutical nanoparticles, drug solution is injected into supercritical carbon dioxide. Supercritical fluids in biomedical and tissue engineering applications. Polyhydroxybutyratecohydroxyvalerate micronization by solution enhanced dispersion by supercritical fluids technique razilian ournal of chemical engineering ol. The supercritical anti solvent technique is a very flexible technique for the micronization of pharmaceutical and natural compounds. Up to now, no examples of micronization of pva by supercritical antisolvent technique have been proposed in the literature. Pdf supercritical antisolvent micronization of some.
Study of particle formation using supercritical co 2 as an antisolvent. Formation of biodegradable polymeric fine particles by. For example, they have been proposed as media for processing biocompatible polymers to develop new products for medical and pharmaceutical applications. The supercritical antisolvent sas technique was used to prepare ethyl cellulosemethyl. Abstract this thesis discusses particle production by supercritical antisolvent processing sas techniques by looking the fundamentals and applications of the method with some case studies. Supercritical fluids in biomedical and tissue engineering. Most frequently, natural or synthetic biopolymers are used as coating. Supercritical antisolvent micronization sas has been used to obtain microparticles of several kind of materials, but the production of nanoparticles have been observed and studied in some cases. Particle formation with supercritical fluids is a promising alternative to conventional precipitation processes as it allows the reduction of particle size and control of morphology and particle size distribution without degradation or contamination of the product. Traditional techniques used to produce micronic powders are. Supercritical antisolvent precipitation of nanoparticles. In the last few years, several supercritical fluidsbased techniques have been proposed for. Supercritical antisolvent micronization of marigold.
Introduction epidemiological evidences suggest that diet rich in fruits and vegetables, both source of antioxidant. The liquid solution and the supercritical antisolvent are continuously delivered to. Micronization of a polysaccharide by a supercritical. Particles of various morphologies were produced at different expansion levels of the liquid solution. Some active pharmaceutical ingredients apis suffer from poor physicochemical. Recent the journal of supercritical fluids articles elsevier. Nanoparticles have attracted more and more attention in the medicinal field. International society for the advancement of supercritical fluids proceedings of the 6 meeting on supercritical fluids. Polymer micronization using batch supercritical antisolvent process. Encapsulation of food compounds using supercritical technologies. Precipitation using supercritical fluids in order to design a supercritical precipitation process several aspects must be taken into account. Preparation of ethyl cellulosemethyl cellulose blends by. We performed experiments on several compounds and different solvents at selected operating conditions, obtaining.
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